Convocatoria 2016 (JTC 2015)

“Immunology and immunotherapy of cancer: strengthening the translational aspects”.

Líneas de investigación de la convocatoria del año 2016 (JTC 2015)

Aim 1: Identification and validation of shared or personalized mutated human tumor antigenic targets.

  • Application of “omics” approaches for the identification and validation of immunogenic mutated epitopes in primary and/or metastatic, synchronous as well as metachronous tumor lesions.
  • Development of ex-vivo and/or in vivo models to be established starting from patients samples for screening immunogenicity and efficacy of personalized vaccines targeting mutated epitopes.

Aim 2: Development of new and combined immunotherapeutic strategies for cancer patients.

  • Development of new vaccine formulations for active immunotherapies, including DNA, RNA vaccines, viral vectors as well as heterologous prime-boost combinations.
  • Development of combined therapeutic approaches including the above antigen-targeting immunotherapies with immune compensating therapies based on irradiation, metronomic chemotherapy and/or anti-immune checkpoint inhibitors and/or adoptive T cell therapies with genetically engineered T cells.
  • Development of interventions directed to counteract the role of tumor microenvironment in immune escape and immune evasion.

Aim 3: Translational research for clinical application of cancer immunotherapy.

  • Identification of intratumoral and/or peripheral blood biomarkers predictive of the efficacy of cancer immunotherapies and establishment of bioassays to monitor the efficacy of cancer immunotherapy.
  • Implementation of new approaches for patient stratification for clinical trials.
  • Design and performance of Phase I and Phase II clinical trials for combined cancer immunotherapy strategies.
  • Toxicity: understanding & anticipating toxicity problems linked to cancer immunotherapy.

The following types of research projects are excluded from the call:


Aviso solicitantes

Se recomienda a las entidades participantes, como socios o coordinadores, en una solicitud en la convocatoria de la ERA-Net TRANSCAN-2, que envíen su presupuesto a transcan-2@ficyt.es, con el fin de realizar una revisión de elegibilidad previa a su envío.

Propuestas

Información sobre los requisitos y ayuda en la presentación de propuestas.

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FICYT

Inscrita en el Registro de Fundaciones Docentes y Culturales de Interés General del Principado de Asturias Nº33/FDC0035.

 

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