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Candidates of excellence wishing to pursue a PhD degree in the field of medical and health sciences: infectious diseases and antimicrobial resistance at ABAC Therapeutics in Barcelona, Spain.

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OFFER DESCRIPTION



 The position


Applications are invited from candidates of excellence wishing to pursue a PhD degree in the field of medical and health sciences: infectious diseases and antimicrobial resistance at ABAC Therapeutics in Barcelona, Spain.

 

The aim of the ESR Project “Development and validation of in vitro tests, and algorithms to predict toxicity” is the develop of innovative tools to deselect compounds that demonstrate antimicrobial activity after the screening process but show relevant adverse effects difficult to counteract. In order to prioritize and select high quality Hits and Lead molecules that meets multiple developability criteria, increasing the possibility to identify robust candidates, reducing technical risk and maximize success to reach the market.

Affiliation to international Phd training network INNOTARGETS

 

The position is affiliated the INNOTARGETs - “Innovative approaches to identification of metabolic targets for antimicrobials” – project, funded through the Horizon 2020 Marie Skłodowska-Curie Actions programme under Grant number 956154.

 

Antimicrobial resistance is a growing medical challenge, hampering the effectiveness of existing drugs and threatening the lives of patients. Therefore, there is a pressing need for compounds that re-sensitise drug-resistant bacteria to existing antimicrobials. To address this problem, the EU-funded INNOTARGETS project will train early-stage researchers in the identification of novel metabolic drug targets in pathogenic bacteria. The project comes as a collaboration between academia and industry and will guide researchers to use innovative approaches to achieve their scientific goals. INNOTARGETS aims to provide ESRs who have scientific and technical skills which are attractive to both industry and academia, are equipped with complementary skills deemed important for research team leaders, and who have an individual profile according to their own career dreams and are capable of life-long self-directed learning. The ESR will work closely together with 11 other early stage researchers (ESRs) in the INNOTARGETS network.

 

About your project

You will contribute to the development and validation of in vitro tests and algorithms to determine toxicity of novel antimicrobial molecules in the project INNOTARGETS (www.Innotargets.ku.dk). Your mission will be the development and validation of in vitro tests, computer tools, as well as the improvement of algorithms to determine and assess the toxicity of compounds that demonstrate antimicrobial activity after the screening process. The goal will be to prioritize and select high quality Hits and Leads molecules that meets multiple developability criteria (weighted profile) and therefore increase the possibility to identify robust candidates, reducing technical risk, and maximize success to reach the market.

Through secondment inside the consortium, the ESR will be exposed to research seen from the side of academic and non-academic institutions, therefore you are expected to spend up to 6 months at Heinrich-Heine-Universitaet Duesseldorf (UDUS), Germany to learn metabolic modelling, and at Institut de Recerca i Tecnologia Agroalimentaries (IRTA), Spain to test prediction on cell cultures.

- The candidate will be enrolled at ABAC Therapeutics (Barcelona, Spain, http://www.abactherapeutics.com/) and must register for PhD at Heinrich-Heine-Universitaet Duesseldorf, Germany (UDUS). 

 

Job description

Your key tasks as a PhD student at ABAC Therapeutics are:


-  Carry through an independent research project under supervision


-  Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points


-  Participate in active research environments including two stays at other research team


-  Obtain experience with teaching or other types of dissemination related to your PhD project


-  Teach and disseminate your knowledge


-  Write a PhD thesis and publish scientific papers on the grounds of your project


Benefits


Terms of employment


The employment as PhD fellow is full time and for 3 years.


It is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant in collaboration with the main supervisor.


The PhD study must be completed in accordance with


a) The Ministerial Order on the PhD programme (2013),


b) the rules and regulations laid down by the European Union’s Horizon 2020 Marie Skłodowska-Curie Action (MSCA) European Training Network, c) and the Faculty’s rules on achieving the degree.


Eligibility criteria


Eligibility and Qualifications  


Applicants must not have resided and not have carried out their main activity (work, studies, etc.) in Spain for more than 12 months in the 3 years immediately before the recruitment date — unless as part of a procedure for obtaining refugee status under the Geneva Convention, and the applicant must be an Early Stage Researcher (ESR) i.e. at the time of recruitment he/she must be in the first 4 years (full-time equivalent research experience) of his/her research careers and must not have been awarded a doctoral degree.


Specific qualifications required to obtain this position can be seen from the job advertisement (link to  job add at your home page, where you should specify specific requirements such as a master degree in one or more specific areas). In general, INNOTARGETS seeks candidates which are able to demonstrate motivation and a strong eagerness to learn, and have the ability to work independently as wells as part of a team. Previous research experience will be a distinct advantage. All fellows must be willing to travel and will be required to complete international secondments.


 


 


Selection process


Application


Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:


1. Motivated letter of application (max. one page)


2. CV incl. education, experience, language skills and other skills relevant for the position


3. Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do


4. Publication list (if possible)


5. Letters of recommendation (if possible)


Additional comments


About ABAC Therapeutics


ABAC Therapeutics is a biotechnology company incorporated in 2014, focused on the discovery and development of precision antimicrobial drugs with pathogen-specific or narrow spectrum activity, with a novel mechanism of action. ABAC is focused primarily on the treatment of infections caused by multi- and extremely resistant organisms.


ABAC, besides innovating disruptively in products, discarding the search for broad-spectrum antibiotics, and focusing on the discovery of compounds with selective activity, has also developed an innovative strategy for drug discovery: PasNas algorithm. The sum of both innovations: product and strategy for drug discovery, gives ABAC a differential character and makes the company a pioneer biotechnology platform in infectious diseases drug discovery.


ABACT Therapeutics promotes equal opportunities among candidates, so there will be no discrimination between gender, religion or nationality.


Web site for additional job details


http://www.abactherapeutics.com


Procedencia EURAXESS
País España
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