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Postdoctoral position on skeletal muscle recovery

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Research project:
Cell therapy offers promising opportunities to approach several diseases for which no effective therapies are currently available. However, the prognosis of the treatment efficacy commonly only relies on the progression of the disease symptoms. There is a need of tools to evaluate and predict the safety and success of cell-based treatments in earlier stages. The current lack of methods providing real-time tracking of transplanted cells and knowledge on their early biodistribution and viability, is one of the major weakness of the available cell-based treatments. The main goal of nTRACK is to develop a safe and highly sensitive multimodal nanoimaging agent enabling noninvasive, quantitative and longitudinal stem cell tracking and whole body biodistribution. nTRACK will also provide information on cell (long-term) viability using the combination of CT, MRI and PET, which are imaging modalities that are clinically available. The synthesis of nTRACK NPs and cellular labeling proc
 esses wi
 ll be scaled up and will follow good manufacturing practice (GMP) requirements. A second goal is to establish a predictive model for early assessment of treatment effectiveness, based on short-term evaluation of the typical migration and biodistribution patterns of the stem cells. This predictive model could substantially improve overall management of the disease and will transform cell therapy treatment from “one size fits all’ concept towards personalised treatment. The nTRACK technology will be demonstrated on a muscular injury animal model, using imaging infrastructure commonly used in hospital settings. In addition, non-clinical safety studies on the nTRACK nanoparticles will be conducted following the conclusions of a series of formal interactions with regulatory authorities, to allow the prompt introduction into clinical trials after the end of the project.

Job position description:
The applicant will work on skeletal muscle recovery testing stem cell therapies in animal studies using mainly imaging (MRI, PET and CT), molecular biology and immunohistology techniques. The studies will focus on evaluating the efficacy of cell therapies and tracking these cells.

Background of the candidate:
PhD in Biology, Biotechnology, Chemistry, etc ... with experience in working with animals, mainly rodents. It is mandatory to have available license for animal handling (FELASA or similar) and experience in molecular biology and immunohistology. On the other hand, familiarization with imaging techniques and any license to work in nuclear facilities (supervisor or operator) will be a plus in the HR selection process.

Labour conditions:
The job will be carry out in the Medical Molecular Imaging Research Group at Vall d’Hebron Research Institute-Vall d'Hebron University Hospital (
Hours: full -time.
Gross annual salary: To be determined in function of the candidate's experience.
Contract length: 1 year (with possibility for extension)

How to apply:
Applicants should submit a full Curriculum Vitae and a cover letter summarizing relevant experience to Two recommendation letters are required

Información complementaria de la oferta:

Procedencia RedIRIS
País España
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