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Marie Curie Post Doc position in the Centre for Genomics and Oncological Research (GENYO): Expression of Interest for Hosting a Marie Curie Fellowship

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Job summary

The group “Genomics of Complex Autoimmune Diseases” leading by Dr Marta E. Alarcón-Riquelme at the GENYO in Granada (Spain) is interested in hosting a Marie Curie Fellowship. Marie Skłodowska-Curie projects are offered to be supervised by Dr Alarcón-Riquelme:

Dr Alarcón-Riquelme has been working in autoimmune diseases. Dr Alarcón-Riquelme discovered the SLE susceptibility gene BANK1. After this, she has been pursuing, among other things, to understand the function of BANK1 in B cells. A recent paper of hers (Wu, et al., PlosONE, 2016) found that BANK1 modulates IgG production. Dr Alarcón-Riquelme is interested to continue this work to understand the mechanisms of BANK1 on IgG production in SLE and normal immunity using mouse models.

Job description

Marie Curie Post Doc position at GENYO (Granada, Spain):

Description of the center:

The Centre for Genomic and Oncology Research (GENYO) is a mixed centre with stakes held by the Regional Ministry of Economy and Knowledge, the Regional Ministry of Health, the University of Granada and the pharmaceutical company Pfizer. This centre has been devised as a space for excellence research in genomic medicine, focusing on the comprehensive study and understanding of the genetic basis of human diseases in general, placing special emphasis on cancer and its genetic disorders related to inheritance. GENYO was created as a multidisciplinary research space, where different professionals from the healthcare, university and business areas interact, making it possible to generate new systems to diagnose, prevent and treat diseases based on the joint and coordinated application of first-rate knowledge in the different areas of genetics.

Description of the group:

The group has been focusing on SLE and autoimmune diseases and has 3 major lines of work: animal models of SLE to understand mechanisms of SLE susceptibility genes, genetics of SLE, in the identification of SLE genes and their fine mapping, and the reclassification of autoimmune diseases using Machine Learning methods and bioinformatics.

Description of the project/projects:

• Project 1 Objective: To understand the function of BANK1 in normal and SLE-related immunity in B cells.

• Project 2 Objective: The effects of BANK1 in extrafollicular Th CD4+ T cells.

Description Principal Investigator:

Dr Alarcón-Riquelme, is the head of Medical Genomics at the Centre for Genomics and Oncological Research and holds a visiting professorship at the Karolinska Institute in Sweden and is adjunct member of the Oklahoma Medical Research Foundation in the USA. She obtained her PhD in Immunology from Stockholms University and has extensive experience in genetics of SLE and Immunology. As a founder member of the International Lupus Genetics Consortium (SLEGEN) she participated in Genome Wide Association Studies (GWAS) that identified several new SLE susceptibility genes.

ORCID ID: 0000-0002-7632-4154

Supervisor Publications:

Dr. Alarcón-Riquelme has an excellent publication record with 164 original peered-reviewed papers and 5 submitted for publication. She is senior author in 53 and has 7 publications in Nature Genetics (four senior author, three co-author), two invited Nature Genetics News & Views and a recent editorial in Nat. Rev. Drug Discov, and has one patent (WO2010-100113A1, PCT patent “BANK related SNPs and SLE and/or MS”). She also has 44 reviews, all invited contributions. She is ad-hoc referee for several high-impact journals (Rheumatology, Science Translational Medicine, The American Journal of Human Genetics, Arthritis & Rheumatology, Nature Genetics, Cell, Arthritis, Research and Therapy, Lupus).

Supervisor International collaborations:

• Founder Member of SLEGEN, 18 prominent lupus genetics researchers from Europe/USA and their groups, supported by the Alliance for Lupus Research and the NIH.

• Chair of BIOLUPUS network, 25 members from Europe, supported by the European Science Foundation (2009-2014).

• Co-coordinator of the multicentre network on the Genome of SLE and RA in Latin America (GENLES and GENAR; composed of >20 centres, voluntary basis).

Supervisor most relevant research projects grants:

• Coordinator of Innovative Medicines Initiative project "Reclassification of Systemic Autoimmune Diseases and the Identification of New Biomarkers" (PRECISESADS), funded by the EU with 18 European Academic centres, 3 SMEs, 5 pharmaceutical companies.

Offer Requirements

    Biological sciences: PhD or equivalent
    Medical sciences: PhD or equivalent
    ENGLISH: Excellent


• Mouse immunology, flow cytometry, cell culture, work with animal crosses, design of mouse crosses.


Specific Requirements

• Main research field: Mouse immunology.

• Sub research field: B cells, Ig switching, B cell subpopulations, flow cytometry and B cell signaling.

• Should have experience in animal models, mainly in mouse immunology and should be in possession of a FELASA C Certificate.

• Years of research experience: >7.

Procedencia EURAXESS
País España
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