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2 PhD positions on Ciliary Signalling in development and disease (SCilS)

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Primary cilia are microtubule-based projections from the cell surface of nearly every cell in our body. In the last two decades it has become clear that primary cilia have evolved to be key signalling hubs of the cells, as they concentrate or segregate components of major cellular signalling pathways.

Dysfunctional cilia can lead to over 35 severe human genetic traits (ciliopathies) with highly heterogeneous, overlapping phenotypes, affecting as many as 1 in 400 people. We now know that humans critically depend on cilia to see, hear, smell, breathe, excrete and reproduce. Such activities require a high degree of regulation and critical feedback to ensure robustness in development and cellular homeostasis of different tissues and organs.

Nijmegen, NL: ESR8 will use three selected Joubert syndrome patient-derived hiPSCs from ciliary protein modules that are differentially localized across the ciliary axoneme, as well as isogenic CRIPSR/Cas9-edited lines for neuronal network measurements using microelectrode arrays (MEAs) and generate a developmental network MEA fingerprint that functionally describes the properties of the neural signalling circuits.

Paris, FR: ESR10 will use cellular and omics analyses (transcriptomic and proteomic) in CRISPR invalidated epithelial cells or urinary epithelial renal cells collected from patients to characterize the pathophysiological processes and determine common and specific signaling pathways altered in patients with NPH. ESR10 will use inhibitors/activators and biosensors (FRET) of the altered pathways to examine their role in NPH-associated phenotype in iPSC-derived kidney organoids and animal models (zebrafish, mouse)

Benefits

    The positions are funded for three years by the EU Marie Curie ITN SCilS, with the intention for 12 months additional funding from other sources to complete the PhD training (if applicable).

Eligibility criteria

Mobility rule:

Applicants should not have resided or performed their main activity in the country of the host institution for more than 12 months in the 3 year period immediately prior to the start date of the fellowship.

Early Stage Researcher:

Applicants should be in the first 4 years (full-time equivalent) of their research careers, including the period of research training, starting at the date of obtaining the degree which would formally entitle them to embark on a doctorate.

Selection process

Applicants should submit:

• a personal statement explaining their motivation and project interests and the contact details of 2 academic referees

• a CV in EU format, other formats are NOT accepted

Please send these documents via email to simone.dusseljee@radboudumc.nl

Intended starting date is September 2020. The positions are open until filled.

PLEASE NOTE that applications that do not meet the requirements WILL NOT BE CONSIDERED.

Web site for additional job details

https://www.scils.eu/



Offer Requirements

    REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
    Neurosciences: Master Degree or equivalent
    REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

    Academic degree (MSc) in molecular life sciences, biomedical sciences or a related discipline.
    A strong background in molecular and cellular neuroscience, cellular biology
    Experience with cell culture, culture of primary neurons and induced pluripotent stem cells.
    Highly motivated to work in an interdisciplinary environment at the cutting edge of science
    Excellent interpersonal and communication skills are essential, as is a willingness to work flexibly

Procedencia EURAXESS
País Holanda
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